The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique

Description

No / A computer simulation based on a Monte-Carlo technique has been developed and used to investigate the influence of pellet size, dispersity, shape and aggregation on the filling of hard shell capsules. The simulations are in general agreement with experimental observations previously reported. The results also confirm recent findings that filling is a function of pellet shape and that above an aspect ratio value of 1.2 filling reproducibility is reduced. The methodology is simple and rapid in execution allowing many computer-based experiments to be performed with minimum effort.

Links & Downloads

1. Rowe, R., Colbourn, E.A., Roskilly, S.J. and York, P. (2005). The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique. International Journal of Pharmaceutics. Vol. 300, No. 1-2, pp. 32-37.
2. http://hdl.handle.net/10454/4127
3. https://doi.org/10.1016/j.ijpharm.2005.05.007

Tags

Pellets

Capsule Filling

Computer Simulation

Monte-Carlo

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4127
Date	January 2005
Creators	Rowe, Raymond C., Colbourn, E.A., Roskilly, S.J., York, Peter
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository