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Previous issue date: 2014-02-26 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The presence of inflammatory cells within the tumor microenvironment plays a dual
role that may contribute both to the progression and for inhibition of tumor growth. Recent
studies suggest that the quality, not the quantity, of the inflammatory infiltrate is the most
important determinant for prognosis. Therefore, TCD8 cells and natural killer cells are the main
effector cells in combating cancer. The aim of this study was to assess, through the
immunohistochemical study, the expression of TCD8 lymphocytes and NK cells in epidermoid
carcinoma (EC) of the lower lip. The sample consisted of 32 specimens of EC of the lower lip,
of which 16 had regional lymph node metastasis, and the 16 remaining, free of metastases. The
total number of positive cells at the front of invasion were evaluated quantitatively and the
results were related to clinical TNM staging, histological grade of malignancy and prognostic
factors. It was observed for the group with metastasis, prevalence of stages III and IV
(p<0.0001). Most patients with metastasis, had a high grade of malignancy (p=0.006). Most
cases classified as high grade of malignancy had stages III and IV (p=0.032). Of the total
sample, there were three cases of recurrence and five with death, however these variables were
not statistically significant when associated with clinicopathological parameters. The
immunostaining of CD8 and CD57, respectively, showed no statistically significant association
with any of the clinicopathological parameters studied, metastasis (p=0.346, p=0.622), TNM
classification (p=0.146, p=0.576), histological grade of malignancy (p=0.936, p=936),
recurrence (p=0.075, p=0.075) and death (p=0.897, p=0.856). Believing in the function of the
immunological system against malignant cells, it is concluded that the TD8 lymphocytes and
NK cells, would be acting in the control of the progression of malignant neoplasms, but not in
isolated manner / A presen?a de c?lulas inflamat?rias dentro do microambiente tumoral exerce um papel
dual podendo contribuir tanto para a progress?o como para a inibi??o do crescimento do tumor.
Estudos recentes sugerem que a qualidade, e n?o a quantidade, do infiltrado inflamat?rio ? o
determinante mais importante para o progn?stico. Portanto, as c?lulas TCD8 e as c?lulas natural
killer (NK), s?o as principais c?lulas efetoras no combate do c?ncer. O objetivo desse trabalho
foi avaliar, atrav?s do estudo imunoistoqu?mico, a express?o dos linf?citos TCD8 e das c?lulas
NK em carcinoma epiderm?ide (CE) de l?bio inferior e sua rela??o com a progress?o da les?o.
A amostra foi composta por 32 esp?cimes de CE de l?bio inferior, dos quais 16 apresentavam
met?stase linfonodal regional, e os 16 restantes, livres de met?stase. O total de c?lulas positivas
no front de invas?o foram avaliados de forma quantitativa e os resultados obtidos foram
relacionados com estadiamento cl?nico TNM, grada??o histopatol?gica de malignidade e
fatores progn?sticos. Observou-se para o grupo com met?stases, preval?ncia dos est?gios III e
IV (p<0,0001). A maioria dos casos com met?stase, apresentava alto grau de malignidade
(p=0,006). A maioria dos casos classificados como de alto grau de malignidade apresentava
est?gios III e IV (p=0,032). Do total da amostra, houve tr?s casos com recidiva e cinco com
?bito, no entanto essas vari?veis n?o apresentaram diferen?a estatisticamente significativa
quando associadas a par?metros clinico-patol?gicos. A imunoexpress?o do CD8 e do CD57,
respectivamente, n?o apresentaram associa??o estatisticamente significativa com nenhum dos
par?metros cl?nico patol?gicos estudados, met?stases (p=0,346; p=0,622); estadiamento
cl?nico TNM (p=0,146; p=0,576) grada??o histopatol?gica de malignidade (p=0,936; p=936);
recidiva (p=0,075; p=0,075) e ?bito (p=0,897; p=0,856). Acreditando na fun??o que o sistema
imunol?gico possui frente a c?lulas malignas, conclui-se que os linf?citos TCD8 e as c?lulas
NK, estariam atuando no controle da progress?o de neoplasias malignas, mas n?o de forma
isolada
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17133 |
| Date | 26 February 2014 |
| Creators | Maciel, Thais Aline Oliveira |
| Contributors | http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787928A2, Costa, Ant?nio de Lisboa Lopes, CPF:32381611487, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786083Z7&dataRevisao=null, Godoy, Gustavo Pina, CPF:85762997472, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4751939A2, Pinto, Le?o Pereira |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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