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Templated interlocked host structures for the recognition and sensing of charged substrates

This thesis describes the synthesis of acyclic, macrocyclic and, in particular, interlocked anion and ion-pair receptors and sensors. <strong>Chapter One</strong> will introduce the field of supramolecular chemistry with particular emphasis on areas which are pertinent to this thesis, including anion receptor design and templated synthesis of interlocked structures. <strong>Chapter Two</strong> focuses on the synthesis of new heteroditopic macrocycles functionalised with both cation and anion recognition sites and their incorporation into interlocked architectures. The affinity for a range of anions and ion-pairs is explored via <sup>1</sup>H NMR and UV-visible spectroscopy as well as by X-ray crystallography. <strong>Chapter Three</strong> details the incorporation of d- and f-metal luminescent reporter groups into an isophthalamide motif in order to construct acyclic, macrocyclic and [2]rotaxane receptors. <strong>Chapter Four</strong> investigates the synthesis of complex higher-order interlocked structures through post-synthetic modification of lower-order interlocked structures. <strong>Chapter Five</strong> explores the potential for fluorescent gold nanoparticle conjugates to act as luminescent and colourimetric sensors for chemical warfare agents (CWAs) by employing a fluorescent displacement assay technique.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:639993
Date January 2014
CreatorsKnighton, Richard C.
ContributorsBeer, Paul D.
PublisherUniversity of Oxford
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttp://ora.ox.ac.uk/objects/uuid:bf8189fa-4409-483b-a3b8-789f0d62c81c

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