N^6,O^2' -Dibutyryl cyclic adenosine 3',5'-monophosphate (Bt_2cAMP) was investigated for its effects on various tissue culture cells infected with temperature-sensitive (ts) mutant, LA31 and Bratislava 77 (B77), a wild-type Rous sarcoma virus. Specifically, known parameters of transformation were investigated and a possible site of action has been tenably proposed. The drug Bt_2cAMP was found to have little effect on the transformation related properties of primary chick embryo fibroblasts (CEF) infected with either virus or normal rat kidney fibroblasts (NRK) infected with the wild-type B77-RSV. However, significant inhibition of the transforming properties in NRK infected with the ts mutant LA31 (LA31-NRK) were reported at the permissive temperature 33 degrees centigrade (33 C).
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc504579 |
| Date | 12 1900 |
| Creators | Marshall, David A. (David Allen) |
| Contributors | Chen, Young C., Johansson, Karl R., Vela, G. Roland, 1927- |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | iv, 50 leaves : ill., Text |
| Rights | Public, Marshall, David A. (David Allen), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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