Obesity is associated with elevated levels of the pro-inflammatory cytokines
interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic
insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and
inflammatory regulator, however circulating FGF21 concentrations are elevated in obese
individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight
individuals, however the effect of acute aerobic exercise on plasma FGF21 response and
the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy
expenditure in obese individuals is unknown. Following 30 minutes of treadmill running
at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with
respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight
subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi,
total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of
glucose and energy metabolism. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_13699 |
| Contributors | Slusher, Aaron L. (author), Huang, Chun-Jung (Thesis advisor), Florida Atlantic University (Degree grantor), College of Education, Department of Exercise Science and Health Promotion |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 54 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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