Revised and corrected version: the year of the author's bachelor’s degree. / Leucine Zipper-like Transcription Regulator 1 (LZTR1) is responsible for encoding a member of the BTB-Kelch superfamily, which interacts with the Cullin3 (CUL3)-based E3 ubiquitin ligase complex. Researchers have discovered mutations in LZTR1 in glioblastoma, schwannomatosis, and Noonan syndrome. However, the exact function of LZTR1 in cancer development or human growth remains unclear. A previous study in the Neel lab showed there was a cell-context dependent regulation of pan RAS (K/N/H RAS) levels by LZTR1. This thesis's main objective was to understand the underlying mechanisms for the above observation. The LZTR1 gene has gained importance in human well-being due to its essential role in cellular activities and its link to various diseases. Investigating the range of functions of LZTR1 and the underlying mechanisms will offer new perspectives on disease prevention and therapeutic approaches. These results provide hints for deciphering the mechanisms of RAS degradation and controlling the RAS/MAPK signaling pathway.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/48392 |
| Date | 13 March 2024 |
| Creators | Ripert, Ryan |
| Contributors | Symes, Karen, Neel, Benjamin |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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