yes / To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging.
Materials and Methods
Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes.
Results
CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021).
Conclusion
CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11801 |
| Date | 08 November 2013 |
| Creators | Beggs, Clive B., Magnano, C.R., Shepherd, Simon J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, Michael G., Carl, Ellen, Weinstock-Guttman, B., Zivadinov, R. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | © 2014 Wiley. This is the peer reviewed version of the following article: Beggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, M. G., Carl, E., Weinstock-Guttman, B. and Zivadinov, R. (2014) Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging. 40: 1215–1222, which has been published in final form at http://dx.doi.org/10.1002/jmri.24468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
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