The effects of pre-stroke exercise and levesl of brain-derived neurotrophic factor (BDNF) on behavioural and functional recovery were examined following focal cortical ischemic infarct.
Intracortical microstimulation (ICMS) was used to derive topographical maps of forelimb
representations within the motor cortex and ischemia was induced via bipolar coagulation of surface vasculature. One month of excerise prior to ischemia significantly increased the
amount of peri-infarct movement represnetations and initiates vascular changes within motor
cortex. Further, this exercise-induced preservation of peri-infarct movement representations is associated with behavioural recovery and is dependent on BDNF levels in the motor cortex. These results provide further support for the idea that endurance exercise prior to stroke
may enhance functional and behavioural recovery. / 140 leaves : ill. (some col.) ; 29 cm.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:ALU.w.uleth.ca/dspace#10133/215 |
| Date | January 2003 |
| Creators | Cooper, Natalie R., University of Lethbridge. Faculty of Arts and Science |
| Contributors | Kleim, Jeffrey |
| Publisher | Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, Arts and Science, Department of Neuroscience |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Relation | Thesis (University of Lethbridge. Faculty of Arts and Science) |
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