This work deals with the preparation and characterisation of poly(n-butyl-2-cyanacrylate) nanocapsules. The mean applications of these particles are their use as drug-carriers, in order to increase the efficiency and to reduce the side effects of pharmaceuticals. By coupling size exclusion chromatography with multi angle laser light scattering a procedure for size determination of nanocapsules is developed. In this connection the analysis of the light scattering data is discussed in detail. Concerning the optimization of the capsule preparation, the influences of different parameters (components concentration, type of stirrer and sample preparation) on the size and size distribution of the nanocapsules are determined. Regarding the characterisation of the polymer cover, the wall thickness as well as the molecular weight distribution of the polymer are analysed. Further, the capsule wall is simulated by a planar polymer film. Rheologic and H-NMR investigations on this film allow to observe the kinetics of wall formation. The rheologic measurements give additional information about the viscoelastic properties and the cross linkage of the polymer.
| Identifer | oai:union.ndltd.org:DUETT/oai:DUETT:duett-07262002-131932 |
| Date | 05 August 2002 |
| Creators | Großpietsch, Uwe |
| Contributors | Prof. Dr. Christian Mayer |
| Publisher | Gerhard-Mercator-Universitaet Duisburg |
| Source Sets | Dissertations and other Documents of the Gerhard-Mercator-University Duisburg |
| Language | German |
| Detected Language | English |
| Type | text |
| Format | text/html, application/pdf |
| Source | http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-07262002-131932/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. Hiermit erteile ich der Universitaet Duisburg das nicht-ausschliessliche Recht unter den unten angegebenen Bedingungen, meine Dissertation, Staatsexamens- oder Diplomarbeit, meinen Forschungs- oder Projektbericht zu veroeffentlichen und zu archivieren. Ich behalte das Urheberrecht und das Recht das Dokument zu veroeffentlichen und in anderen Arbeiten weiterzuverwenden. |
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