The visual pigment of vertebrates (rhodopsin), a member of the large class of G-protein-coupled receptors, and the photosynthetic pigment bacteriorhodopsin of halobacterium salinarum, an active pump, contain retinal as prosthetic group. The replacement of the native retinal by analogue chromophores helps to understand the molecular function of the light sensitive ligands. In order to study the intermolecular interaction between chromophore and protein three retinal derivatives were synthesized and incoporated (9-desmethylretinal, 9-ethylretinal and 9-isopropylretinal) which together with the native chromophore constitute a homologous series with systematically changed size of the substituent at position 9. In addition three analogue retinals with modification at position 10 and/or 13 (10-methylretinal, 13-demethylretinal and 10-methyl-13-demethylretinal) were also synthesized and studied particulary to understand the intramolecular interaction of the chromophore of rhodopsin.
| Identifer | oai:union.ndltd.org:DUETT/oai:DUETT:duett-07172001-082136 |
| Date | 17 July 2001 |
| Creators | Ockenfels, Andreas |
| Contributors | Döpp, Dieter; Prof. Dr., Gärtner, Wolfgang; Prof. Dr. |
| Publisher | Gerhard-Mercator-Universitaet Duisburg |
| Source Sets | Dissertations and other Documents of the Gerhard-Mercator-University Duisburg |
| Language | German |
| Detected Language | English |
| Type | text |
| Format | text/html, application/pdf |
| Source | http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-07172001-082136/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. Hiermit erteile ich der Universitaet Duisburg das nicht-ausschliessliche Recht unter den unten angegebenen Bedingungen, meine Dissertation, Staatsexamens- oder Diplomarbeit, meinen Forschungs- oder Projektbericht zu veroeffentlichen und zu archivieren. Ich behalte das Urheberrecht und das Recht das Dokument zu veroeffentlichen und in anderen Arbeiten weiterzuverwenden. |
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