In Saccharomyces cerevisiae, zinc cluster proteins form a major family of transcriptional regulators for a variety of processes, yet many putative zinc cluster proteins have unknown functions. Previous studies assigned phenotypes to some of these proteins, a few of which showed previously unknown functions in pleiotropic drug resistance (PDR). The first study presented here focuses on a phenotypic analysis of double deletion mutants to further our understanding on functional relationships among zinc cluster proteins that mediate PDR. The second study focuses on a newly characterized zinc cluster protein, Asg1p, and its functional role in regulating stress response genes. In both studies, we found that the relationship among zinc cluster proteins is highly complex and tightly regulated.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.98514 |
| Date | January 2006 |
| Creators | Wai, Carol. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Biochemistry.) |
| Rights | © Carol Wai, 2006 |
| Relation | alephsysno: 002328941, proquestno: AAIMR24821, Theses scanned by UMI/ProQuest. |
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