A new benzannulation reaction was discovered. The reaction involves intramolecular attack into a carbon-carbon triple-bond by the alpha position of a beta-ketoester under acidic conditions. Four different beta-ketoester starting materials were prepared and were successfully cyclized. This benzannulation methodology should provide a convenient pathway for forming aromatic products to be used as building blocks in the syntheses of anti-tumor antibiotics.
| Identifer | oai:union.ndltd.org:RICE/oai:scholarship.rice.edu:1911/13913 |
| Date | January 1994 |
| Creators | Weiss, Trent Jason |
| Contributors | Ciufolini, Marco A. |
| Source Sets | Rice University |
| Language | English |
| Detected Language | English |
| Type | Thesis, Text |
| Format | 95 p., application/pdf |
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