A new approach to the ribosyl-ribitol unit of the capsular polysaccharide of Haemophilus influenzae type b (Hib) was developed. Oligomers (n = 1-5) of the polysaccharide attached to a ribose spacer were synthesized. These compounds have potential use as a synthetic vaccine component for immunization against Hib meningitis. / An attempt to synthesize fragments of Escherichia coli K100 bacteria polysaccharide which is cross-reactive with the Hib polysaccharide was made. / In connection with the synthesis of Goniothalenol, a new protecting group, the $p,p sp prime$-dinitrobenzhydryl ether was developed. The formation and removal of this protecting group was described.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75949 |
| Date | January 1989 |
| Creators | Chan Chun Kong, Laval |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000909922, proquestno: AAINL52426, Theses scanned by UMI/ProQuest. |
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