<p> Molecular oxygen is an ideal source of oxygen atoms for synthetic transformations because it is inexpensive, abundant, and non-toxic. This dissertation presents the development of synthetic methods to oxidize alkenes to α-oxygenated ketones, hydroperoxides, alcohols, and endoperoxides using molecular oxygen under transition-metal or ambient-light catalysis. Chapter One describes a copper-catalyzed method to afford α-oxygenated ketones that can be further functionalized to give a variety of products. Chapter Two offers a light-catalyzed method for the synthesis of hydroperoxides from enol ethers and strained alkenes. Chapter Three discusses a cobalt-catalyzed synthesis of 1,2-dioxolanes and their applications in cancer biology. Chapter Four presents preliminary work in the construction of 1,2-dioxanes, which can be manipulated to furnish biologically active natural product derivatives.</p><p>
| Identifer | oai:union.ndltd.org:PROQUEST/oai:pqdtoai.proquest.com:10929113 |
| Date | 20 November 2018 |
| Creators | Andia, Alexander A. |
| Publisher | New York University |
| Source Sets | ProQuest.com |
| Language | English |
| Detected Language | English |
| Type | thesis |
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