Block copolymers were made containing peptides coupled to a hydrophobic regions that could be cleaved to obtain a hydrophilic region, similar to globular proteins. These polymers were synthesized by anionic polymerization of t-butyl acrylate followed by coupling with polypeptides. Anionic polymerization allowed control of molecular weight, polydispersity as well as end groups of the polymer. The polymer was terminated with a carboxylic acid or a primary amine, the desired end groups needed to couple this polymer to peptides by conventional peptide coupling reactions. Upon hydrolysis of the esters, the resulting hydrophilic-hydrophobic polymer may be used to act as specific channels through lipid membranes, to increase the solubility of peptides in hydrophilic and hydrophobic solvents or to modify particle growth of inorganic salts.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/278374 |
| Date | January 1993 |
| Creators | Mollberg, William Carl, 1967- |
| Contributors | Hall, H. K., Jr. |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Thesis-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
Page generated in 0.0122 seconds