Ammonium-containing polyacrylamide resins, ammonium-containing polystyrene resins, and their metal-ion coordinated analogs have been synthesized for the sorption of bile salts (BS). The effects of altering the backbone, the type of ammonium group, the number of ammonium group, the hydrophobicity of the pendant group, and of varying the metal ions on the adsorption of BS's, were studied to elucidate the structure-activity relationship. / The binding capacity of the resins for BS's generally increased with increasing number of ammonium groups per pendant group of the ammonium-bearing resins, and with higher charge of the metal complex cation of the metal-ion coordinated resin, demonstrating the primary importance of electrostatic interactions. It was also observed that, as the resin backbone was changed from hydrophilic polyacrylamide to hydrophobic polystyrene, the adsorption capacity increased substantially, demonstrating that hydrophobic interactions (H-H's) between the resin backbone and the BS's also play a significant role in the binding. The incorporation of hydrophobic segments -(CH$ sb2) sb{ rm n}$- into the pendant groups on polyacrylamide resins increased binding capacity, but had no effect for the more hydrophobic polystyrene resins. Primary ammonium-bearing resins often showed higher binding capacities than their quarternary analogs, suggesting that H-bonding reinforces the binding. Isotherms with an S-shape observed for most polyacrylamide resins indicate a positive cooperativity in the binding due to H-H's and H-bonding among BS anions bound at adjacent positions within resin beads. Binding models have been proposed to depict the formation of pendant group-BS mixed reversed micelles and ordinary BS micelles. / The studies of the kinetics of the binding of BS anions by the resins showed that a small resin particle size and more intense shaking substantially increase the rate of binding. This indicates that the binding process is mainly controlled by the diffusion of BS anions near and within the beads. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.70362 |
| Date | January 1990 |
| Creators | Wu, Gaoming |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001312625, proquestno: AAINN80324, Theses scanned by UMI/ProQuest. |
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