A novel approach to natural product synthesis is presented herein which encompasses three original functionalization processes. These are; (a) the direct photochemical conversion of alkenes to spiro-activated cyclopropanes, (b) the homoconjugate addition of organo-magnesium reagents to said cyclopropanes, and (c) the ozonolysis of isopropylidene malonate enolates. An application of this new methodology to the partial synthesis of racemic brefeldin A is then described.
| Identifer | oai:union.ndltd.org:RICE/oai:scholarship.rice.edu:1911/15563 |
| Date | January 1979 |
| Creators | LIVINGHOUSE, THOMAS STUART |
| Source Sets | Rice University |
| Language | English |
| Detected Language | English |
| Type | Thesis, Text |
| Format | application/pdf |
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