There are some examples where conformational restriction has been introduced into nucleotides with the sole purpose of increasing the thermodynamic stability of the duplex or triplex between the modified oligonucleotide and its complement. This thesis explored the hypothesis of incorporating a cyclopropane moiety into the internucleotide linkage. This research demonstrates the successful synthesis of a novel cyclopropanated sulfonamide dinucleotide 19.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE MAI) / This novel molecule has been synthesized by reacting an $ alpha, beta$ unsaturated phenylselenoyl nucleotide derivative 7 with an active methylene sulfonamide nucleotide 17 under Michael addition conditions. Binding studies concerning the cyclopropanated sulfonamide dinucleotide 19 are pending.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.22784 |
| Date | January 1995 |
| Creators | Nower, Peter |
| Contributors | Just, G. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Chemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001461778, proquestno: MM05608, Theses scanned by UMI/ProQuest. |
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