Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe

Description

Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe.Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with HIV infection than in those without it ( RR= 2.32, 95% CI-1.38-3.92). No CCR5-Δ32 deletion was detected in the studied population. Conclusion: The homozygous CCR2V64I gene and STIs were more prevalent in HIV infected pregnant women than in uninfected pregnant women and no homozygous CCR5-Δ32 gene was detected in this study.

Links & Downloads

1. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4983_1319103621

Tags

HIV in pregnant women

Host genetic factors

Gene polymorphism

Mutation

Protective effect

CCR5-Δ32 CCR2V64I

Vaccines

Chemotherapeutic drugs

Zimbabwe.

Additional Fields

Identifer	oai:union.ndltd.org:UNWC/oai:UWC_ETD:http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_4983_1319103621
Date	January 2010
Creators	Soko, White
Source Sets	Univ. of Western Cape
Language	English
Detected Language	English
Type	Thesis and dissertation
Format	Pdf
Coverage	ZA
Rights	Copyright: University of the Western Cape