The control of synthesis of the cell-wall polymer chitin has been implicated as a crucial event in yeast - hyphal dimorphism of the pathogenic fungus, <i>Candida albicans</i>. This thesis presents evidence that suggests that the activity of the zymogenic enzyme, chitin synthase, is modulated by an endogenous activatory metalloprotease <i>in vitro</i>. The proposed activating protease is characterised and partially purified. A comparison of the intracellular proteolytic activity of yeast and hyphal cells suggest that hyphal cell may be nutrient-stressed compared to yeast cells.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:383472 |
| Date | January 1986 |
| Creators | McDougall, G. J. |
| Publisher | University of Aberdeen |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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