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The regulation of chitin synthesis in Candida albicans

The control of synthesis of the cell-wall polymer chitin has been implicated as a crucial event in yeast - hyphal dimorphism of the pathogenic fungus, <i>Candida albicans</i>. This thesis presents evidence that suggests that the activity of the zymogenic enzyme, chitin synthase, is modulated by an endogenous activatory metalloprotease <i>in vitro</i>. The proposed activating protease is characterised and partially purified. A comparison of the intracellular proteolytic activity of yeast and hyphal cells suggest that hyphal cell may be nutrient-stressed compared to yeast cells.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:383472
Date January 1986
CreatorsMcDougall, G. J.
PublisherUniversity of Aberdeen
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation

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