Degradation of peroral administered drugs by various enzymes in the gastrointestinal
tract has proven to be troublesome for the absorption' and bioavailability of protein and
peptide drugs. Mucoadhesive polymers such as poly(acrylates) have proven to inhibit
protease enzymes responsible for initiating digestion of peptide drugs. Enzyme inhibitors
have unique chemical properties enabling it to interact with enzymes to form complexes
with such enzymes prohibiting it from functioning properly. Anionic carboxymethylated
chitosan derivatives such as N,N-dicarboxymethyl chitosan and N, O-carboxymethyl
chitosan display unique structural similarities to enzyme inhibitors being anionic
polymers that may interact with bi-valent cations... / Thesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:nwu/oai:dspace.nwu.ac.za:10394/245 |
| Date | January 2003 |
| Creators | Oberholzer, Ian Dewald |
| Publisher | North-West University |
| Source Sets | South African National ETD Portal |
| Detected Language | English |
| Type | Thesis |
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