Reduced bioavailability in some formulations of phytosterols accounts for the variable results observed in LDL- C- lowering efficacy among trials. This study examined the effects of a water-dispersible formulation of free phytosterols (WD-PS) versus phytosterol esters (PS-esters) on plasma lipid and fat soluble vitamins concentrations in hypercholesterolemic individuals. Using a double-blind, randomized, crossover study, 47 hypercholesterolemics were provided for 4 wk: WD-PS-enriched yogurt (2g/d), PS-esters-enriched yogurt (2g/d), or yogurt alone (placebo), in a random order. Each study phase was separated by 4 wk washout intervals. Supplementation of WD-PS or PS-esters similarly decreased serum TC (7.7% and 6.3%, respectively) and LDL-C levels (11.7% and 11.6%, respectively, p<0.001). The ratio of TC/ HDL-C decreased for WD-PS (10.6%, p<0.05) but not for PS-esters. Moreover, WD-PS reduced serum TG (13.9%, p<0.05) as compared to PS-esters (0.6%). The results of the current study confirm the importance of the formulation of phytosterols in their bioavailability and efficacy.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:MWU.1993/5255 |
| Date | 04 April 2012 |
| Creators | Amir Shaghaghi, Mandana |
| Contributors | Jones, Peter (Human Nutritional Sciences, Food Sciences), Mymin, David (Medicine) Moghadasian, Mohammad (Human Nutritional Sciences) Harding, Scott (Diabetes and Nutritional Sciences Division, King's College, London, United Kingdom) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Detected Language | English |
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