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Use of fluorescence in situ hybridization (FISH) for studying centromere organization and centric fusions in cattle

Includes bibliograpical references (leaves 119-134). The most common chromosome abnormalities in live cattle are various Robertsonian translocations (centric fusions). Two hypotheses have been used to explain how monocentric Robersonian translocation chromosomes are generated: either direct formation, or evolution from dicentic chromosomes. Four main cattle procentric Satellite sequences were used as single and two-colour fluorescence in situ hybridization probes for studying the centromere organisation of cattle autosomes and the rearrangement in two cattle Robertsonian translocation chromosomes, the t(1:29) which is monocentric and found in numerous breeds, and the t(14:20) which is dicentric and found in 2 breeds.

Identiferoai:union.ndltd.org:ADTP/91589
Date January 1998
CreatorsZheng, Jianze.
Source SetsAustraliasian Digital Theses Program
LanguageEnglish
Detected LanguageEnglish
RelationSUA, SUA:R

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