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Previous issue date: 2012-01-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Embryo transfer (ET) is one of the most prominent techniques in the expansion of horse
breeding, enabling the production of more products of a single mare per year, thus increasing
the number of animals with high genetic value. The hormonal control of ovulation can be
used as a tool to optimize the reproductive parameters and reduce the costs in an ET program.
This study compared the effectiveness of lower doses than those traditionally used of
Deslorelin and hCG, evaluating the time between ovulation and induction, the recovery rates
and embryo attachment. The study was conducted at the Department of Animal Reproduction
and Evaluation of UFRRJ. We conducted follow-up of 85 estrous cycles of Breton Postier and
Mangalarga Marchador mares, when the mares presenting an ovarian follicle ? 35 mm, they
were divided randomly into one of three treatments: G1 (n = 32) - treatment with 1000 IU (1.0
ml iv) of hCG (Chorulon ? - Intervet Schering-Plough Animal Health), G2 (n = 28) -
treatment with 0.75 mg (0.75 ml iv) Deslorelin (Botupharma) and G3 (n = 28) - Treatment
with 1.0 ml saline iv. Twenty four hours after application, ultrasound evaluation of ovarian
was held every six hours up to ovulation. The donors were inseminated the day after induction
and embryo collection took place in nine days after ovulation. The recovered embryos were
immediately transferred to recipients previously synchronized, these pregnancy diagnosis was
performed at 15 and 30 days old embryo. Data regarding the time between ovulation and
induction and characteristics of follicular development were analyzed using analysis of
variance (ANOVA), and the averages of these data were analyzed when needed by the Tukey
test. The data regarding the percentage of mares ovulated in different periods, were analyzed
using the Qui-quadrado (?2) 5%. In the case of embryo recovery rate, the data were analyzed
using the Fisher exact test, however in relation to pregnancy rate was not possible to perform
statistical analysis due to low sample size. The percentage of ovulation in up to 36 hours for
G1, G2 and G3 were 34.4%, 13.3% and 8.7%, between 36 and 42 hours were 62.5%, 56.7%
and 8.7%, from 42 to 48 hours were 0%, 20% and 13%, more than 48 hours were 3.1%, 10%
and 69.6% respectively. Having thus a significant difference between treated and control
groups (p <0.05). The embryo recovery rate was 75% (6/8) in G1 and G2, and 44.4% (4/9) in
group G3, there was no significant difference between groups (p> 0.05). The rate of
pregnancy at fifteen days old embryo was 69.2% (9/13). Thus the lower doses commonly
used with inducing agents in question, were effective in promoting ovulation within 48 hours,
but the use of these didn't result in significant improvement in the rates of embryo recovery. / A transfer?ncia de embri?es (TE) ? uma das t?cnicas de maior destaque na expans?o da
equideocultura, possibilitando a produ??o de maior n?mero de produtos de uma mesma ?gua
por ano, aumentando assim o n?mero de animais com alto valor gen?tico. O controle
hormonal do momento da ovula??o pode ser usado como uma ferramenta para otimizar os
par?metros reprodutivos e reduzir os custos em um programa de TE. O presente estudo
comparou a efici?ncia de doses mais baixas do que as tradicionalmente utilizadas de hCG e
Deslorelina avaliando o tempo entre a indu??o e a ovula??o, as taxas de recupera??o e fixa??o
embrion?ria. O estudo foi desenvolvido no Departamento de Reprodu??o e Avalia??o Animal
da UFRRJ. Foi realizado o acompanhamento de 85 ciclos estrais de ?guas da ra?a Bret?o
Postier e Mangalarga Marchador, onde as ?guas ao apresentarem um fol?culo ovariano ? 35
mm foram divididas de maneira aleat?ria em um dos tr?s tratamentos: G1 (n = 32) ?
tratamento com 1000 UI (1,0 ml i.v.) de hCG (Chorulon? - Intervet Schering-Plough Animal
Health), G2 (n = 30) ? tratamento com 0,75 mg (0,75ml i.v.) de Deslorelina (Botupharma) e
G3 (n=23) ? tratamento com 1,0 ml i.v. de solu??o salina. Vinte quatro horas ap?s a
aplica??o, a avalia??o ultrassonogr?fica dos ov?rios passou a ser realizada a cada seis horas
at? a detec??o da ovula??o. As ?guas doadoras foram inseminadas no dia seguinte a indu??o e
as coletas de embri?o aconteceram no dia 9 ap?s a ovula??o. Os embri?es recuperados foram
imediatamente transferidos para receptoras previamente sincronizadas, sendo o diagn?stico de
gesta??o realizado aos 15 e 30 dias de idade embrionaria. Os dados referentes ao tempo entre
indu??o e ovula??o e caracter?sticas do desenvolvimento folicular, foram analisados pelo
m?todo de An?lise de Vari?ncia (ANOVA), sendo as m?dias desses dados analisadas quando
necess?rio pelo teste de Tukey. Os dados referentes ao percentual de ?guas ovuladas em
diferentes per?odos, foram analisados atrav?s do Qui-quadrado (?2) 5%. Em se tratando da
taxa de recupera??o embrion?ria, os dados foram analisados atrav?s do teste Exato de Fisher,
j? em rela??o a taxa de gesta??o n?o foi poss?vel realizar an?lise estat?stica devido ao baixo
n?mero amostral. Os percentuais de ovula??o em at? 36 horas nos grupos G1, G2 e G3, foram
34,4 %, 13,3% e 8,7%, entre 36 e 42 horas, 62,5%, 56,7% e 8,7%, entre 42 e 48 horas, 0%,
20% e 13%, acima de 48 horas 3,1%, 10% e 69,6%, respectivamente. Havendo dessa maneira
diferen?a significativa entre os grupos tratados e o controle (p < 0,05). A taxa de recupera??o
embrion?ria foi de 75% (6/8) nos grupos G1 e G2 e 44,4% (4/9) no grupo G3; n?o houve
diferen?a significativa entre os grupos (p > 0,05). J? a taxa de gesta??o aos quinze dias de
idade embrion?ria foi de 69,2% (9/13). Deste modo as doses inferiores ?s comumente
utilizadas, dos agentes indutores em quest?o, foram eficientes em promover a ovula??o em at?
48 horas, mas o uso destes, n?o resultou em melhora significativa nos ?ndices de recupera??o
embrion?ria
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1198 |
| Date | 25 January 2012 |
| Creators | Silva, Paula Cardoso de Almeida |
| Contributors | Jacob, J?lio Cesar Ferraz, Dell' Aqua Junior, Jos? Antonio, Mello, Marco Roberto Bourg de |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas), UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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