Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au₂S nanoparticles was controlled by the pH value of solution, and the drug release was sensitive to NIR irradiation. The cis-platin loaded Au-Au₂S nanoparticles can be potentially applied as NIR activated drug delivery carrier. / Singapore-MIT Alliance (SMA)
| Identifer | oai:union.ndltd.org:MIT/oai:dspace.mit.edu:1721.1/3787 |
| Date | 01 1900 |
| Creators | Ren, L., Chow, Gan-Moog |
| Source Sets | M.I.T. Theses and Dissertation |
| Language | en_US |
| Detected Language | English |
| Type | Article |
| Format | 101640 bytes, application/pdf |
| Relation | Molecular Engineering of Biological and Chemical Systems (MEBCS); |
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