Chromatographic separation of acetone/methylene chloride extracts of Formosan soft coral Capnella imbricata (GN75) led to the isolations of six new capnellenes, 8b,10a-diacetoxy-D9(12)-capnellene (1), D9(12)-capnellene-5b,8b,10a-triol (3), D9(12)-capnellene-8b,10a,13b-triol (4), 8b-acetoxy-D9(12)
-capnellene (7), D9(12)-capnellene-8b,14b-diol (8), D9(10)-capnellene-12-ol-8-one (9), and three known compounds, D9(12)-capnellene-8b,10a-diol (2), D9(12)-capnellene-10a-ol-8-one (5), D9(12)-capnellene-8b-ol (6), one new calamenene, (+)-15-hydroxy-calamenene (10).
One new prostanoid, GN61-97-11-8 (11) and five new steroids, GN61-91-141-14 (12), GN61-91-141-12 (13), GN61-77-6-I (14), GN61-77-6-E (15) and GN61-97-9-6 (16) were isolated from the methylene chloride extracts of the Formosan soft coral Clavularia viridis (GN61).
All of these compounds were established on the basis of extensive spectral analysis and chemical reactions. The absolute structure of 2 was determined by MTPA esterifications. Compounds 1-3¡B5 and 12-16 showed more specific inhibition against the up-regulation of the pro-inflammatory iNOS and COX-2 proteins of LPS-stimulated RAW264.7 macrophage cells.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0717107-114033 |
| Date | 17 July 2007 |
| Creators | Chang, Chin-hsiang |
| Contributors | Chang-Yih Duh, Jyh-Horng Sheu, Zhi-Hong Wen |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717107-114033 |
| Rights | not_available, Copyright information available at source archive |
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