Dysfunctional reward processing and disinhibitory tendencies have been highlighted as central to the development and maintenance of
substance use disorders (SUDs). The literature emphasizes two different interpretations of the reward dysfunction observed in individuals with
SUDs – one being that substance-free reward dysfunction arises as a consequence of repeated substance use, and the other being that
substance-free reward dysfunction is mainly a liability for subsequent substance use. Further complicating these accounts are recent findings
demonstrating a moderating role of disinhibition on the relationship between reward sensitivity and SUDs. The proposed work aimed to address
these unresolved complexities in the literature by examining interactions between disinhibition and neural reward sensitivity (operationalized
via nucleus accumbens [NAcc] activation in the monetary incentive delay [MID] task) in predicting substance problems assessed concurrently and
across time. While disinhibition showed to be a robust liability factor for substance problems, demonstrating strong predictive value both
concurrently and prospectively, age 14 NAcc activation was not related to substance problems as a main effect nor in an interactive manner.
Additionally, dysfunctional NAcc activation was not a consequence of adolescent substance use either, as substance problems from age 14 to 19
was not predictive of the change in NAcc activation between age 14 and 19. However, NAcc activation appeared to be a concurrent co-determinant
of substance problems at age 19 – disinhibition and NAcc activation interacted to predict substance problems such that those high in
disinhibition with blunted NAcc activation showed the most problems. / A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for the degree of
Master of Science. / Fall Semester 2018. / August 8, 2018. / Drug/Substance Use, Neuroimaging, Reward Sensitivity / Includes bibliographical references. / Christopher J. Patrick, Professor Directing Thesis; Greg Hajcak, Committee Member; Christopher
Schatschneider, Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_661151 |
| Contributors | Joyner, Keanan J. (Keanan Joel) (author), Patrick, Christopher J. (professor directing thesis), Proudfit, Greg Hajcak (committee member), Schatschneider, Christopher (committee member), Florida State University (degree granting institution), College of Arts and Sciences (degree granting college), Department of Psychology (degree granting departmentdgg) |
| Publisher | Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text, master thesis |
| Format | 1 online resource (68 pages), computer, application/pdf |
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