Aquaporin-4 (AQP4) is a key component in maintaining proper glymphatic flow. In recent years, the glymphatic system has been discovered and approached as a major factor in amyloid plaque clearance in Alzheimer's disease. This study examines the depolarization of AQP4 from the astrocytic endfeet and subsequent co-localization with amyloid plaques in the hippocampus and subiculum. Results show a significant pattern of co-localization in advanced Alzheimer's disease, as well as increases in AQP4 in cerebrovascular disease. This pattern shows AQP4 should be approached as a promising therapeutic area in future research.
Identifer | oai:union.ndltd.org:BGMYU2/oai:scholarsarchive.byu.edu:etd-8441 |
Date | 01 July 2017 |
Creators | Crum, Anthony Bryan |
Publisher | BYU ScholarsArchive |
Source Sets | Brigham Young University |
Detected Language | English |
Type | text |
Format | application/pdf |
Source | Theses and Dissertations |
Rights | http://lib.byu.edu/about/copyright/ |
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