Background:
Prior studies regarding the risk factors of mild cognitive impairment (MCI), such as physical activity (PA) and sleep related factors in older Chinese populations are scarce, and the findings have not been consistent.
Objectives:
1. To cross-sectionally and longitudinally examine the dose-response association between PA and cognitive function by Delayed Word Recall Test (DWRT) or Mini-mental State Examination (MMSE).
2. To cross-sectionally and prospectively examine the association of sleep related factors, including sleep duration, daytime napping, morning tiredness and insomnia, with cognitive function.
Design:
Cross-sectional and longitudinal analysis using both baseline and follow-up data from the GBCS.
Methods
Baseline data from 8,451 men and 22,067 women aged 50 years or above were used for the cross-sectional analysis. Among them, 4,214 men and 11,284 women participating in the second examination were included in the longitudinal analysis. Information on demographic, socioeconomic and lifestyle factors, and personal disease history was collected. Cognitive function was assessed by MMSE and DWRT under standardized protocols.
Results
1. Significant dose-response relations across quintiles of metabolic equivalent
value (METs) with DWRT score in participants with or without good self-rated health were found in cross-sectional analysis (all P for trend <0.001).
2. Prospectively, compared to those who were physically active, those with moderate activity or inactivity had increased risk for MCI. Regarding daily walking time, subjects with walking of 0.5 to 1 h, or ≥1 h had significantly reduced risk of MCI by 25% and 31% respectively compared with those who walked < 0.5 h per day. Subjects with low PA level at both baseline and follow-up had a significantly higher risk of MCI than those reporting PA at both baseline and follow-up.
3. Cross-sectionally, after adjustment for a range of potential confounders, an inverted U-shaped association between sleep duration and DWRT score was found, with 7 to 8 h of habitual sleep duration showing the highest score (P-values for trend from 3 to 7 h and from 7 to ≥10 h were all ≤0.001). Subjects with daily napping, morning tiredness, or insomnia had lower DWRT score than those without (P ranged from <0.001 to 0.01).
4. Prospectively, after adjustment for multiple risk factors, compared to sleep duration of 7 hours per day, those with sleep duration of 5 hours or less had increased risk for MCI by 43%. The adjusted P value for the linear trend from sleep duration of 3 hours to 7 hours per day was 0.01. The association remained after excluding those with poor health status. No significant associations of daytime napping, morning tiredness and insomnia with MCI were found.
Conclusions
In summary, we found a significant dose response association between PA and cognitive function in both cross-sectional and longitudinal analysis. One hour of daily walking is recommended for older Chinese people to delay or prevent cognitive decline. Short or long sleep duration may also be an important predictor of mild cognitive impairment. Sleep duration of less than 6 hours per day may indicate an increase risk of cognitive impairment in older people. / published_or_final_version / Community Medicine / Doctoral / Doctor of Philosophy
| Identifer | oai:union.ndltd.org:HKU/oai:hub.hku.hk:10722/179986 |
| Date | January 2012 |
| Creators | Xu, Lin, 徐琳 |
| Contributors | Lam, TH, Schooling, CM |
| Publisher | The University of Hong Kong (Pokfulam, Hong Kong) |
| Source Sets | Hong Kong University Theses |
| Language | English |
| Detected Language | English |
| Type | PG_Thesis |
| Source | http://hub.hku.hk/bib/B48521772 |
| Rights | The author retains all proprietary rights, (such as patent rights) and the right to use in future works., Creative Commons: Attribution 3.0 Hong Kong License |
| Relation | HKU Theses Online (HKUTO) |
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