Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, September, 2020 / Cataloged from student-submitted PDF version of thesis. / Includes bibliographical references (pages 76-90). / During social interactions, humans and social animals can distinguish not only familiar and novel conspecifics (social recognition) but also between multiple familiar individuals (social specification). Recent studies have implicated hippocampal sub-region dorsal CA2 (dCA2) in social recognition and identified social recognition memory engram in downstream ventral CA1 (vCA1). However, the anatomical site for the storage of social specification memory and its underlying neuroscientific mechanisms are poorly known. Here, we report that social specification memory engrams are stored in vCA1 while social information encoded in dCA2 becomes sharpened as it travels from dCA2 to vCA1 microcircuits within CA2, thereby acquiring a progressive increase in specification through repeating motifs of feed-forward inhibition. Both the inhibition of GABAergic inhibitory neurons in CA2 and reduced activity of excitatory neurons by ablation of oxytocin receptors in the dCA2 to vCA1 microcircuits impair social memory specification. These results suggest that the vCA1 and the multiple feed-forward inhibition motifs in the dCA2 to vCA1 microcircuits are crucial for social memory specification. / by Rosary Yuting Lim. / Ph. D. in Neuroscience / Ph.D.inNeuroscience Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences
| Identifer | oai:union.ndltd.org:MIT/oai:dspace.mit.edu:1721.1/130185 |
| Date | January 2020 |
| Creators | Lim, Rosary Yuting. |
| Contributors | Susumu Tonegawa., Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences., Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| Publisher | Massachusetts Institute of Technology |
| Source Sets | M.I.T. Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 90 pages, application/pdf |
| Rights | MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided., http://dspace.mit.edu/handle/1721.1/7582 |
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