The role of κ agonist U-50,488H in cSNC was explored in four experiments. Experiment one revealed that U-50 failed to influence cSNC on trial 11 but showed both an attenuation with low dose of U-50 and exaggeration of cSNC in medium and high dose of U-50 by impairing recovery. Experiment two confirmed a selective attenuation for trial 12 of cSNC in groups given low dose, while the medium dose impaired recovery. Experiment three explored the possibility that the effects of U-50 on cSNC may be the result of an influence on alternative mechanisms such as locomotor activity. Results revealed that U-50 showed no influence from saline control. Experiment four explored the effects of U-50 on posttrial 11 and revealed that U-50 signficantly enhanced contrast, on trial 12, indicating an effect on associative mechanisms involved in the memory of the downshift experience.
| Identifer | oai:union.ndltd.org:TCU/oai:etd.tcu.edu:etd-07262006-161404 |
| Date | 26 July 2006 |
| Creators | Wood, Michael David |
| Contributors | Mauricio R Papini, Jennifer Higa |
| Publisher | Texas Christian University |
| Source Sets | Texas Christian University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf, application/msword |
| Source | http://etd.tcu.edu/etdfiles/available/etd-07262006-161404/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to TCU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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