Hepatitis C, the disease caused by the Hepatitis C Virus (HCV), infects over three million people in the United States alone. In the majority of infected individuals, the virus sets up chronic infection and can ultimately result in liver cancer. The NS5A protein of HCV is thought to provide the virus with means to evade detection by the host immune system and provide resistance to interferon and inhibit apoptosis, or programmed cell death. These mechanisms of apoptotic interference by HCV may be what ultimately lead to hepatocellular carcinoma, the 3rd leading cause of cancer death. This project characterizes the behavior of cell lines that stably expresses NS5A, and their response to apoptotic stimuli. The research aims are to understand how NS5A interferes with apoptosis by identifying what apoptotic proteins it binds to.
| Identifer | oai:union.ndltd.org:TCU/oai:etd.tcu.edu:etd-10162009-114805 |
| Date | 16 October 2009 |
| Creators | Subramanian, Shilpi |
| Contributors | Giri R Akkaraju |
| Publisher | Texas Christian University |
| Source Sets | Texas Christian University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf, application/msword |
| Source | http://etd.tcu.edu/etdfiles/available/etd-10162009-114805/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to TCU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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