The focus of this work lies on the exploitation of hypophosphorous derivatives in order to develop new methodologies for P-C bond formation as well as synthesizing biologically relevant phosphorus compounds.
A review of the work published to date from the Montchamp group is provided in Chapter 1: Much of the methodology is applied in the remainder of the thesis in reactions such as radical addition, base-promoted alkylation and cross-coupling of anilinium hypophosphite. The following chapter describes initial results of the transition-metal catalyzed cross-coupling in the presence of beta-hydrogens and with chloromethylphthalimide. The application of phosphine-borane chemistry as a phosphinylidene protecting group is discussed in Chapter 3. An in-depth literature review provides the background for the new methodology. Novel gamma-aminobutyric acid analogues are synthesized using methods developed within the Montchamp group. Their synthesis and biological evaluation are discussed in the final chapter.
| Identifer | oai:union.ndltd.org:TCU/oai:etd.tcu.edu:etd-12052006-094447 |
| Date | 05 December 2006 |
| Creators | Tellez, Jennifer Lynn |
| Contributors | Jean-Luc G Montchamp |
| Publisher | Texas Christian University |
| Source Sets | Texas Christian University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf, application/msword |
| Source | http://etd.tcu.edu/etdfiles/available/etd-12052006-094447/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to TCU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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