This study investigated the mechanisms that mediate cocaines effects on self-control and impulsive behavior in rats. Rats were exposed to a discrete-trials self-control procedure in which a lever press to one lever produced 1 pellet of food following a 1 s delay and a lever press to the opposite lever produced 3 pellets of food following a 3 s delay. Rats were given 0 ,7.5, 15 and 30 mg/kg of cocaine and 0, .01, .10 and 1.0 mg/kg of the 5-HT3 receptor antagonist Ly-278,584 separately and in combination with each other to assess the effects of 5HT3 receptor inhibition on cocaines effects on self-control. Results revealed a decrease in self-control when the two drugs were administered together. Therefore, results support past research suggesting that serotonergic and dopaminergic systems play a role in mediating the behavioral effects of cocaine.
| Identifer | oai:union.ndltd.org:TCU/oai:etd.tcu.edu:etd-12082006-143442 |
| Date | 08 December 2006 |
| Creators | Dandy, Kristina Leigh |
| Contributors | Jennifer J Higa |
| Publisher | Texas Christian University |
| Source Sets | Texas Christian University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf, application/msword |
| Source | http://etd.tcu.edu/etdfiles/available/etd-12082006-143442/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to TCU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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