Return to search

DEVELOPMENTS IN SIGNAL AMPLIFICATION BY REVERSIBLE EXCHANGE (SABRE) OF 15N AND 13C NUCLEI TOWARDS APPLICATIONS IN MRI

Signal Amplification by Reversible Exchange (SABRE) is a hyperpolarization technique that utilizes parahydrogen for the NMR signal enhancement of nuclear spins. SABRE is related to Parahydrogen Induced Polarization (PHIP), another means of hyperpolarization using parahydrogen; PHIP achieves hyperpolarization via chemical reduction. Although PHIP and SABRE share many similarities in experimentation, PHIP ultimately requires the presence of an unsaturated chemical bond as well as pairwise-addition of parahydrogen. No permanent chemical change occurs during SABRE, and instead may be considered as a merely physical exchange between molecules with sites on a catalyst. PHIP and SABRE may be compared to Dynamic Nuclear Polarization (DNP), arguably the most well-known and researched method for hyperpolarization; despite all that has been achieved with DNP, PHIP and SABRE offer vastly more-rapid, less-expensive, and more-simplified approaches for achieving hyperpolarization. The focus of this work is experimentation with SABRE processes and methods designed to overcome certain experimental challenges associated with this technique.

Identiferoai:union.ndltd.org:siu.edu/oai:opensiuc.lib.siu.edu:theses-3530
Date01 May 2019
CreatorsMashni, Jamil Assad
PublisherOpenSIUC
Source SetsSouthern Illinois University Carbondale
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceTheses

Page generated in 0.0016 seconds