A computer model for simulating experiments done on surface organelles(so called pili) on the Escherichia Coli bacteria have been developedand implemented. The objective of the computer simulation wasto mimic the results of experiments done with optical tweezers and to displaya graphical, three dimensional, representation of these experiments.The experiments measured the force response to elongation of pili.This force response can be divided into three regions of elongation, regionI, II and III, each with different properties. Region I is characterized by aconstant increase in force, in region II the pilus is unfolded under constantforce, and in region III the force versus elongation curve assumes a nontrivialshape with increasing force. The pili are also able to retract to itsoriginal length giving a similar force response curve. The computer modelshould be able to handle all these properties. The developed model couldhandle elongation in region I and II. In region III, the force response givenby the simulation differed from the one given by the experiments.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:umu-94715 |
| Date | January 2008 |
| Creators | Svebilius, Christian |
| Publisher | Umeå universitet, Institutionen för fysik |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
Page generated in 0.0019 seconds