The present study investigated the neural mechanisms by which environmental stimuli guide conditioned behaviors in the amphetamine conditioned place preference (CPP) paradigm. Systemically injected D1 and D2 dopamine antagonists blocked both acquisition and expression of the CPP: the selective D1 antagonist more effectively blocked expression than the D2 antagonists. The site of action of the antagonists on expression was the nucleus accumbens. Systemically injected reserpine, but not intra-accumbens a-MPT microinjections, also blocked the expression of the amphetamine CPP. Pre-conditioning and post-conditioning electrolytic or excitotoxic lesions of the lateral amygdaloid nucleus impaired the CPP. It was concluded that the effect of conditioned incentive stimuli is mediated by a neural system which involves the reserpine-sensitive dopamine pool and the D1 dopamine receptor in the nucleus accumbens and the lateral amygdaloid nucleus.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.74669 |
| Date | January 1991 |
| Creators | Hiroi, Noboru, 1961- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001236486, proquestno: AAINN67809, Theses scanned by UMI/ProQuest. |
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