The statistical correlations between habitual diet and plasma
risk factors for coronary heart disease CHD were analyzed using
multiple regression. Thirty-one male subjects between 30-56 years
kept complete dietary records for 7 days. Daily means of nutrient
consumption were calculated using a computerized data base.
Fourteen independent variables (total kilocalories, protein %,
carbohydrate %, fat %, ethanol %, caffeine, P/S ratio, cholesterol,
age, weight, height , weight**.75, Body Mass Index,
kilocalories/weight**.75) were created. Plasma samples were analyzed
and the following simple (total plasma cholesterol (TC), VLDL-C,
LDL-C, HDL2-C, HDL3-C, apo A-I, apo A-II, apo B) and derived
(VLDL-C+LDL-C, LDL-C/TC, LDL-C/HDL-C, HDL-C, HDL2-C/HDL3-C, HDL-C/TC,
apo B/apo A-I, apo B/apo A-II, apo A-Il/apo A-I) dependent variables
were created. Dependent variables were individually regressed against the entire set of independent variables. An F-value of 4.00
to enter an independent variable in the model and of 3.99 to remove
one were used to achieve significance of p<05.
Age appeared in 5 regression models (TC, apo B, apo B/apo A-I,
apo B/apo A-II, apo A-Il/apo A-I) and was positively correlated with
increased risk for CHD. Total kilocalories appeared in 4 models
(LDL-C, apo B, VLDL-C+LDL-C, LDL/TC) and was negatively correlated
with risk. Fat % appeared in 4 models (VLDL-C+LDL-C, LDL/TC,
LDL-C/HDL-C, HDL-C/TC) and was associated with increased risk. Body
Mass Index was entered in 2 models (HDL2-C, HDL-C) and was positively
correlated with risk. P/S ratio was negatively correlated with risk
in the three models (HDL2, apo A-I, HDL-C) in which it appeared. The
independent variable carbohydrate % was negatively associated with
risk in 2 models, LDL-C and apo B. Kcal/wt**.75 was also negatively
correlated with risk in the VLDL-C, LDL-C/TC and HDL-C/TC models.
One independent variable, EtOH %, was positively associated with risk
in the apo A-II and apo A-II/apo A-I models. Two dependent variables
did not have any independent predictors (HDL3-C, HDL2-C/HDL3-C)
entered in their regression models.
Six independent variables did not appear in any regression
model (protein %, caffeine, cholesterol, weight, height,
weight**.75). Independent variables positively correlated with
increased risk for CHD were therefore fat %, ethanol %, age, and Body
Mass Index. Independent variables correlated with decreased risk for
CHD were total kilocalories, carbohydrate %, P/S ratio, and
kilocalories/weight**.75. / Graduation date: 1985
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27429 |
| Date | 08 August 1984 |
| Creators | Bills, Nathan D. |
| Contributors | Oh, Suk Y. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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