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The Adenosine Antagonist Aminophylline Attenuates Pacing-Induced Coronary Functional Hyperemia

Left coronary blood flow (LCBF), left ventricular oxygen, extraction [(a-v)O₂ ], and myocardial oxygen consumption (MVO₂) were monitored in 10 dogs. HR was paced at 120 bpm and then increased to 180 bpm to elicit a hyperemic response (ΔLCBF). During the hyperemia, the vaso-dilatory response to exogenous adenosine (F_AD) was tested. Twenty min. after injection of aminophylline (100 mg/i.v.), HR was again increased. F_AD was again tested. The pacing-induced increase in MVO₂ (ΔMVO₂) was not affected by aminophylline (P>0.05). However, the slope ΔLCBF/ΔMVO₂ was decreased, and the slope (a-v)O₂ /ΔMVO₂ was increased. F_AD was also decreased and the magnitude of the reduction was correlated with the decrease in ΔLCBF/ΔMVO₂ (r=0.82). These results suggest that adenosine may play an role in coronary functional hyperemia induced by increases in heart rate.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc504435
Date12 1900
CreatorsRandall, John Robert
ContributorsJones, Carl E., Sinclair, Richard J., Barker, David J., Harris, Ben G.
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatv, 72 leaves: ill., Text
RightsPublic, Randall, John Robert, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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