Submitted in fulfilment of the Master’s Degree in Clinical Technology,
Durban University of Technology, 2012. / The sirolimus-eluting stent (Cypher) was the first approved drug-
eluting stent by the Food and Drug Administration in April 2003. This is a stent
that is based on a bare-metal stent and is coated with a layer of polymer
incorporating sirolimus and releasing it by diffusion. Drug-eluting stents
reduced risk of restenosis and repeat revascularization as compared with
bare-metal stents. Clinical data has raised concerns that drug-eluting stents
are associated with late untoward events.
Objectives: The objective of this study was to test the hypothesis that stenting
is safe and effective treatment for coronary artery disease.
Methods and Results: Sirolimus-eluting stenting was performed in 30 patients
with 34 coronary lesions. Detailed clinical follow-up data was collected by
personal interview or telephone contact at 1, 6, 12 and 24 months. Patients
were followed for 2 years for the occurrence of angina and cardiovascular
events namely death, myocardial infarction, stent thrombosis and target lesion
revascularization. The mean age of the cohort was 62.33±10.99 years; 83
percent were male, 6 percent were diabetic, 53 percent had hypertension. In
spite of the overall patient and lesion complexity there were no incidences of
major adverse cardiac events and all patients remained angina free out to two
years. Dual antiplatelet therapy with aspirin and plavix varied from at least
four weeks to one year. One patient had a bleeding event.
Conclusions: Treatment of lesions with sirolimus-eluting stents is associated
with a sustained clinical benefit two years after device implantation.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:dut/oai:localhost:10321/812 |
| Date | 18 January 2013 |
| Creators | Harrypaul, Ashika |
| Contributors | Adam, Jamila Khatoon, Dyer, Robby B. |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 90 p |
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