<p>The development of alcohol use
disorder (AUD) is believed to involve functional adaptations in corticostriatal
projections which regulate the reinforcing properties of ethanol (EtOH). To
further our understanding of how repeated EtOH consumption impacts the
corticostriatal circuit, extracellular electrophysiological recordings (local
field potentials; LFPs) were gathered from the nucleus accumbens and prefrontal
cortex of female and male C57BL/6J mice voluntarily consuming EtOH or water
using ‘drinking-in-the-dark’ (DID) procedures. Mice were given 15 consecutive
days of two-hours of access to EtOH (20% v/v), three hours into the dark cycle
while LFPs were recorded. To determine the impact of repeated EtOH consumption
on neural activity between these brain regions, theta phase-locking value (PLV,
a measure of synchrony) was calculated. Specifically, theta PLV was calculated
during active drinking periods (bouts) and average PLV during the first bout was
compared to the last bout to determine within session changes in synchrony. Results
indicated significantly lower PLV during the last bout than the first bout.
Additionally, longer bouts predicted lower PLV during the last bout, but not
the first bout when mice were consuming EtOH. These results may suggest that alcohol intoxication
decreases corticostriatal synchrony over a drinking period. Results considering changes in
theta power spectral density (PSD) indicated an increase in PSD when mice were
given access to water during the typical EtOH access time following the 15-day
EtOH drinking history. This effect was not seen when mice were drinking water
prior to EtOH access and may be indicative of a successive negative contrast
effect. This work identifies unique functional characteristics of
corticostriatal communication associated with binge-like EtOH intake and sets
the stage for identifying the biological mechanisms subserving them.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/13303694 |
| Date | 30 November 2020 |
| Creators | Cherish Elizabeth Ardinger (9706763) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/DETERMINING_THE_IMPACT_OF_REPEATED_BINGE_DRINKING_ON_CORTICOSTRIATAL_THETA_SYNCHRONY/13303694 |
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