Poly(N-vinylcaprolactam), PNVCL, is a nonionic, nontoxic, water soluble, thermally
sensitive and biocompatible polymer. It contains hydrophilic carboxylic and amide
groups with hydrophobic carbon-carbon backbone chain so its hydrolysis does not
produce small amide compounds which are often not desired for biomedical
applications. Moreover PNVCL possesses lower critical solution temperature,
(LCST) in the range of physiological temperature (32-34 oC). These properties make
the polymer suitable for use in some biotechnology applications such as implantation
of artificial organs and tissues, purification of enzymes, proteins and living cells, and
in drug release systems.
In this study PNVCL was synthesized by free radical polymerization with solution
technique. Polymerization was done at different temperatures for different time
periods in an oil bath. The activation energy for polymerization was found from
Arrhenius plot as 108.4 kJ/mol. Polymer was characterized by FT-IR, 1H-NMR and
13C-NMR, DSC, TGA and XRD techniques. FT-IR and NMR measurements
confirmed that the polymerization proceeded through the vinyl group.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12609947/index.pdf |
| Date | 01 September 2008 |
| Creators | Kozanoglu, Selin |
| Contributors | Usanmaz, Ali |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for public access |
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