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Previous issue date: 2008-09-23 / Alcohol is one of the few psychotropic drugs that their consumption has admitted legally and sometimes encouraged by the society. Studies show alcohol as the highest consumption of drugs among young people and society in general, probably because of its availability and easy access. The abuse causes public health problems, which was closely related to the violence, socioeconomic problems and the high number of automobile accidents. Transit is one of the main sectors affected by the effects of alcohol, observing a high incidence in the studies. About half of automobile accidents occurs after the consumption of alcoholic beverage, and the vast majority of cases related to high concentrations of alcohol in the bloodstream. The relationship of drunk with traffic accidents is in fact evident everywhere in the world, including Brazil, where studies have shown a high relationship between alcohol consumption and traffic accidents. This study determined the alcohol in fatal victims of traffic accidents in the state of Rio Grande do Norte and established the profile of this population compared with those found in Brazil and other countries. Samples of blood of ethanol added to fulfillment of the standardization of chromatographic conditions and procedures for the analysis, being employed in the determination of alcohol in blood samples of 277 victims of traffic accidents, collected at the Institute of Scientific Technical Police of Rio Grande do North (ITEP) in the year 2007. The blood alcohol level was determined in these samples correlated with the sex, age and marital status of the victim and the location, day of week and month when the accident occurred, is doing a statistical analysis and outlining a profile of the victims of an accident at transit in the state of Rio Grande do Norte. The parameters of standardization studied ensured the quality of the analytical method and, consequently, to obtain reliable laboratory results. Being given the best temperature for injector (150 ?C), detector (250 ?C) and column (50 ?C) with a flow of gas in the column of 2mL/minutos and analysis of time of 12 minutes. The method was linear in the range of 0.01 to 3.2 g / L (r2 = 0.9989) with average recovery of 100.2% and precision with coefficient of variation less than 15%. The analysis carried out on victims of fatal road traffic accidents, ethanol detected in the blood in 66.43% of the victims and these, 96% showed concentration ≥ 0.2 g / L, 87.73% of victims were male, while 12.27% female. The younger age group (1535 years) was the most involved (52,35%) and most single (55.60%). The accidents occurred with greater prevalence in the day on Monday (27%) followed by Sunday (24,19%) and Saturday (15,52%) and it was found that the prevalence of injuries varied between the different months of the year, and in February (14.4%) and April (10.47%) the months that had a higher number of accidents, however this oscillation showed no statistically significant difference. Also no significant difference was observed between the tracks of concentration found in men and women. The standardized method showed to be efficient, given satisfactorily to the goals of this work, and the high levels of alcohol found in victims of fatal road traffic accidents are consistent with several studies of literature, and the profile of the victim also supported by presenting in its most young adults, male and single / O ?lcool ? uma das poucas drogas psicotr?picas que tem seu consumo admitido legalmente e, ?s vezes, incentivado pela sociedade. Estudos mostram o ?lcool como a droga de maior consumo entre os jovens e na sociedade de forma geral, provavelmente devido ? sua disponibilidade e f?cil acesso. O uso abusivo provoca problemas de sa?de p?blica, estando ele estreitamente relacionado com a viol?ncia, problemas s?cioecon?micos e com o elevado n?mero de acidentes automobil?sticos. O tr?nsito ? um dos principais setores afetados pelos efeitos do ?lcool, observandose alta incid?ncia nos estudos realizados. Aproximadamente metade dos acidentes automobil?sticos ocorre ap?s o consumo de bebida alco?lica, estando a grande maioria dos casos relacionados com altas concentra??es de ?lcool na circula??o sangu?nea. A rela??o da embriagues com os acidentes de tr?nsito ? fato not?rio em toda parte do mundo, inclusive no Brasil, onde estudos demonstraram uma alta rela??o entre o consumo de ?lcool e os acidentes de tr?nsito. Este trabalho determinou a alcoolemia em v?timas fatais de acidente de tr?nsito no Estado do Rio Grande do Norte e estabeleceu o perfil desta popula??o comparando com aqueles encontrados no Brasil e em outros pa?ses. Foram utilizadas amostras de sangue adicionadas de etanol para realiza??o da padroniza??o das condi??es cromatogr?ficas e dos procedimentos de an?lise, sendo empregado na determina??o da alcoolemia em amostras de sangue de 277 v?timas de acidente de tr?nsito, coletadas no Instituto T?cnico Cient?fico de Pol?cia do Rio Grande do Norte (ITEP) no ano de 2007. O n?vel de alcoolemia determinado nestas amostras foi correlacionado com o sexo, idade e estado civil da v?tima e com a localiza??o, dia da semana e m?s em que os acidentes ocorreram, fazendose uma an?lise estat?stica e tra?ando um perfil das v?timas de acidente de tr?nsito no estado do Rio Grande do Norte. Os par?metros de padroniza??o estudados asseguraram a qualidade do m?todo anal?tico e, conseq?entemente, a obten??o de resultados laboratoriais confi?veis. Sendo determinado as melhores temperaturas para injetor (150?C), detector (250?C) e coluna (50?C), com um fluxo de g?s na coluna de 2mL/minutos e tempo de an?lise de 12 minutos. O m?todo foi linear no intervalo de 0,01 a 3,2 g/L (r2 = 0,9989), com recupera??o m?dia de 100,2% e precis?o com coeficiente de varia??o menor que 15%. As an?lises realizadas em v?timas fatais de acidente de tr?nsito, detectaram etanol no sangue em 66,43% das v?timas e destas, 96% apresentaram concentra??o ≥ 0,2 g/L; 87,73% das v?timas eram do sexo masculino, enquanto que 12,27% do sexo feminino. A faixa et?ria jovem (1535 anos) foi a mais envolvida (52,35%) sendo a maioria solteira (55,60%). Os acidentes aconteceram com maior preval?ncia nos dias de segundafeira (27%), seguido do domingo (24,19%) e s?bado (15,52%) e constatouse que a preval?ncia de acidentes oscilou entre os diferentes meses do ano, sendo fevereiro (14,4%) e abril (10,47%) os meses que apresentaram um maior n?mero de acidentes, contudo esta oscila??o n?o apresentou diferen?a estatisticamente significativa. Tamb?m n?o foi observado diferen?a significativa entre as faixas de concentra??o encontradas nos homens e nas mulheres. O m?todo padronizado demonstrouse eficiente, atendendo satisfatoriamente aos objetivos deste trabalho; e os n?veis elevados de alcoolemia encontrados nas v?timas fatais de acidente de tr?nsito s?o coincidentes com v?rios estudos da literatura, sendo o perfil da v?tima tamb?m compat?vel, apresentandose em sua maioria adultos jovens, do sexo masculino e solteiros
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13440 |
| Date | 23 September 2008 |
| Creators | Santiago, Edna de Farias |
| Contributors | CPF:31482015404, http://lattes.cnpq.br/2959800336802498, Carvalho, Jos? Melo de, CPF:07124872472, http://lattes.cnpq.br/3824079454047896, Schwarz, Aline, CPF:03065039648, http://lattes.cnpq.br/2401319567715548, Gl?ria, Maria Beatriz Abreu, CPF:20359772668, http://lattes.cnpq.br/6895373188728113, Moura, Maria de F?tima Vit?ria de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias Farmac?uticas, UFRN, BR, Bioan?lises e Medicamentos |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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