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Role of Repressors in Fine Regulation of Development: Sxl and Its New Repressors Hey and Myc

In Drosophila, XX embryos express Sxl from the early promoter, SxlPe, and
become females. At the same time, XY embryos with only one X chromosome become
males.
I investigated the role of repression in the establishment of the strict regulation of
SxlPe. I found that the co-repressor Groucho, is responsible for amplification of the
two-fold difference in X-encoded activator genes into an all-or-nothing difference in Sxl
expression. Three new basic helix-loop-helix repressors of Sxl were identified: Hey,
Cwo and the prooncogene Myc, all of which are maternally supplied. I have shown that
Myc specific repression is important as early as cycle 10, which is 2 cycles earlier than
the onset of normal Sxl expression.

Identiferoai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-2009-12-7419
Date2009 December 1900
CreatorsKozhina, Elena
Source SetsTexas A and M University
LanguageEnglish
Detected LanguageEnglish
TypeBook, Thesis, Electronic Thesis, text
Formatapplication/pdf

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