Flaviviruses (genus Flavivirus, family Flaviviridae) includes a number of medically and veterinary important arboviruses. Most of them are transmitted by mosquitoes, such as West Nile virus, yellow fever virus, dengue virus or Zika virus. In the last decade, there has been discovered number of flaviviruses which have not known vertebrate host. They are called insect-specific flaviviruses (ISFs). These viruses have been detected in dipteran insects (mostly in mosquitoes) from all over the world. It seems they induce no pathogenic changes even in insect and they are not able to infect any vertebrate cells. However in some recent studies has been shown that some ISFs could influence the replication of other medically important flaviviruses in mosquito cells. In addition, they probably represent an ancestrial lineage of the family Flaviviridae and further studies focused on them could help to clarify which characteristics of flaviviruses enable them to infect vertebrates. There is not a lot of information about the ecology of ISFs and it is suggested that most ISFs have not been discovered yet. Main goal of this thesis was to detect ISFs in mosquitoes in the Czech Republic, where have not been made any exstensive research of these viruses yet. In case of discover some undiscribed ISFs we wanted to characterize...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:348343 |
| Date | January 2016 |
| Creators | Majerová, Karolina |
| Contributors | Votýpka, Jan, Kopecký, Jan |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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