Most of the cardiac structural abnormalities will be examined by echocardiography. With more understanding of heart diseases, it is commonly recognized that heart failures are closely related to left ventricular systolic and diastolic functions. This work discusses the association between gray-scale differences and the risk of heart disease from the changes in left ventricular systole and diastole of ultrasound image. Owing to the large dimension
of data matrix, following Chen (2011), we also simplify the influence factors by factor analysis and calculate factor scores to present the characteristics of subjects.
Two kinds of classification criteria are used in this work, namely logistic model with distance indicator and discriminant function. According to Guo et al. (2001), we calculate the Mahalanobis distance from each subject to the center of normal and abnormal group, then use logistic model to fit the distances for classification later. This is called logistic model with distance indicator. For the discriminant analysis, the regularized method by Friedman (1989) for estimation of covariance matrix is used, which is more flexible and can improve the covariance matrix estimates when the sample size is small. As far as the
cut-point of ROC curve, following the approach as in Hanley et al. (1982), we find the most appropriate cut-point which has good performances for both sensitivity and specificity under the same classification criteria. Then the regularized method and the cut-point of ROC curve are combined to be a new classification criterion. The results under the new
classification criterion are presented to classify normal and abnormal groups.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0708111-161254 |
| Date | 08 July 2011 |
| Creators | Kao, Li-wen |
| Contributors | Mei-Hui Guo, Mong-Na Lo Huang, Chung Chang, Fu-Chuen Chang, May-Ru Chen, Kai-Hsien Hsieh |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708111-161254 |
| Rights | not_available, Copyright information available at source archive |
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