Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. PharmDr. Zdenka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Andrea Suther Bunes Title of Thesis: Study of influence of hydrophilic carriers on the dissolution rate of a BCS II drug The aim of this thesis was to study the effect of mixing and co-milling with hydrophilic carriers on the dissolution rate of a model BCS II drug meloxicam. The mixtures of two different drug loads (1-1, 1-8) were characterized for granulometric and dissolution parameters. USP-4 apparatus assembled with a flow-through powder cell (an open loop) was used to estimate meloxicam relative dissolution rate rrel (min-1 ). Mixing with lactose, particularly in a higher ratio, increased the relative dissolution rate in comparison to the pure meloxicam. The effect was further increased by co-milling, but an unfavourable event of agglomeration occurred, especially for the 1-1 drug-excipient ratio sample. Adding chitosan solved this problem due to the formation of interactive mixture. The co-milled sample containing chitosan and lactose in a 1-8 ratio showed the highest rrel = 0.48 min-1 .
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:446240 |
| Date | January 2021 |
| Creators | Bunes, Andrea Suther |
| Contributors | Šklubalová, Zdeňka, Vraníková, Barbora |
| Source Sets | Czech ETDs |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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