Introduction: One characteristic of Alzheimer’s disease is the formation of amyloid-b plaques, which
are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and
infiltrating immune cells.
Methods: Here, we describe nonneurogenic doublecortin (DCX) positive cells, DCX being generally used as a marker for young immature neurons, at sites of amyloid-b plaques in various transgenic
amyloid mouse models and in human brains with plaque pathology.
Results: The plaque-associated DCX1 cells were not of neurogenic identity, instead most of them
showed coexpression with markers for microglia (ionized calcium-binding adapter molecule 1) and for
phagocytosis (CD68 and TREM2). Another subpopulation of plaque-associated DCX1 cells was negative
for ionized calcium-binding adapter molecule 1 but was highly positive for the panleukocyte marker
CD45. These hematopoietic cells were identified as CD3-and CD8-positive and CD4-negative T-cells.
Discussion: Peculiarly, the DCX1/ionized calcium-binding adapter molecule 11 microglia and
DCX1/CD81 T-cells were closely attached, suggesting that these two cell types are tightly interacting and that this interaction might shape plaque pathology.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:94501 |
| Date | 21 November 2024 |
| Creators | Unger, Michael S., Marschallinger, Julia, Kaindl, Julia, Klein, Barbara, Johnson, Mary, Khundakar, Ahmad A., Roßner, Steffen, Heneka, Michael T., Couillard-Despres, Sebastien, Rockenstein, Edward, Masliah, Eliezer, Attems, Johannes, Aigner, Ludwig |
| Publisher | Elsevier |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1552-5260, 10.1016/j.jalz.2018.02.017 |
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