[ES] La tesis doctoral "Nanostructured supports for the detection of pathogens and biomolecules of interest based on molecular gates with oligonucleotides" se centra en el diseño de nanomateriales híbridos orgánico-inorgánicos como biosensores innovadores para la detección rápida y específica de patógenos como el virus del papiloma humano (VPH) y la bacteria Vibrio vulnificus, así como biomoléculas relevantes como miR-4732-3p, relacionado con la cardiotoxicidad en pacientes con cáncer. Los sensores desarrollados, basados en puertas moleculares en alúmina mesoporosa y validados con muestras clínicas, destacan por su alta sensibilidad, especificidad, rapidez y facilidad de uso, lo que los hace prometedores para aplicaciones en diagnóstico y monitoreo ambiental. / [CA] The doctoral thesis "Nanostructured supports for the detection of pathogens and biomolecules of interest based on molecular gates with oligonucleotides" focuses on the design of organic-hybrid nanomaterialsInorganic as innovative biosensors for rapid and specific detection of pathogens such as human papillomavirus (HPV) and the bacterium Vibrio vulnificus, as well as relevant biomolecules such as miR-4732-3p, related to cardiotoxicity in cancer patients. The developed sensors, based on mesoporous alumina molecular gates and validated with clinical samples, stand out for their high sensitivity, specificity, speed and ease of use, which makes them promising for applications in diagnosis and environmental monitoring. / [EN] La tesi doctoral "Nanostructured supports for the detection of pathogens and biomolecules of interest based on molecular gates with oligonucleotides" se centra en el disseny de nanomaterials híbrids orgànic-inorgànics com biosensors innovadors per a la detecció ràpida i específica de patògens com el virus del papil·loma humà (VPH) i el bacteri Vibrio vulnificus, així com biomolècules rellevants com miR-4732-3p, relacionat amb la cardiotoxicitat en pacients amb càncer. Els sensors desenrotllats, basats en portes moleculars en alúmina mesoporosa i validats amb mostres clíniques, destaquen per la seua alta sensibilitat, especificitat, rapidesa i facilitat d'ús, la qual cosa els fa prometedors per a aplicacions en diagnòstic i monitoratge ambiental. / This research was supported by project PID2021-126304OB-C41 funded by MCIN/AEI and by European Regional Development Fund - A way of doing Europe. This work has received funding from the European Union’s Horizon 2020 Development of an Innovative Fluorogenic Biosensor for Direct Detection of Vibrio vulnificus, a Climate Change Biomarker research and innovation programme under grant agreement No 899708.
This research was also supported by CIBER -Consorcio Centro de Investigación Biomédica en Red (CB06/01/2012), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación. This study forms part of the Advanced Materials programme (MFA/2022/049) and was supported by MCIN with funding from European Union NextGeneration EU (PRTR-C17.I1) and by Generalitat Valenciana. The study was also supported by the grants PID2020-120619RB-I00 funded by MCIN/AEI and CIAICO/2021/293 funded by “Conselleria de Educación, Universidades y Empleo” (Generalitat Valenciana,
Spain). / Aranda Sobrino, MDLN. (2024). Nanostructured Supports for Detection of Pathogens and Biomolecules of Interest Based on Molecular Gates with Oligonucleotides [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/211237
| Identifer | oai:union.ndltd.org:upv.es/oai:riunet.upv.es:10251/211237 |
| Date | 03 November 2024 |
| Creators | Aranda Sobrino, María de las Nieves |
| Contributors | Aznar Gimeno, Elena, Martínez Mañez, Ramón, Universitat Politècnica de València. Departamento de Química - Departament de Química, Generalitat Valenciana, Agencia Estatal de Investigación |
| Publisher | Universitat Politècnica de València |
| Source Sets | Universitat Politècnica de València |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/doctoralThesis, info:eu-repo/semantics/acceptedVersion |
| Rights | http://rightsstatements.org/vocab/InC/1.0/, info:eu-repo/semantics/openAccess |
| Relation | info:eu-repo/grantAgreement/GVA//CIAICO%2F2021%2F293, info:eu-repo/grantAgreement/CIBER//CB06%2F01%2F2012/, info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-120619RB-I00/ES/INTERACCION HOSPEDADOR-PATOGENO EN VIBRIO VULNIFICUS: NUEVAS ESTRATEGIAS DE CONTROL Y DIAGNOSTICO/, info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126304OB-C41/ES/NUEVOS MATERIALES Y SONDAS PARA EL RECONOCIMIENTO, LIBERACION DE FARMACOS, NANOMOTORES Y COMUNICACION |
Page generated in 0.0032 seconds